upstream bioprocessing market share, upstream bioprocessing market demand, upstream bioprocessing market trends, upstream bioprocessing market statistics, upstream bioprocessing market size, upstream bioprocessing market forecast
How big is the upstream bioprocessing market today, and what are its future growth expectations?
The upstream bioprocessing market size has grown rapidly in recent years. It will grow from $12.03 billion in 2024 to $13.66 billion in 2025 at a compound annual growth rate (CAGR) of 13.6%. The growth in the historic period can be attributed to rise in need for process optimization and contamination free, safe and efficient production of biomolecules, commercial success and rising demand for bio-therapeutics, rise in the implementation of process analytical technology, rise in chronic disease prevalence, and increased research into the production of biosimilar.
The upstream bioprocessing market size is expected to see rapid growth in the next few years. It will grow to $22.43 billion in 2029 at a compound annual growth rate (CAGR) of 13.2%. The growth in the forecast period can be attributed to commercial use of single-use bioreactors, outsourcing of biopharmaceutical manufacturing, rapid growth of pharmaceutical and biotechnology industries, rising adoption of single-use upstream bioprocessing, and increasing partnerships, mergers, acquisitions, and collaborations. Major trends in the forecast period include increasing investments in R&D in biopharmaceutical industry, technological advancements, advanced upstream bioprocessing technologies, development of new technologies and advanced filtration technologies.
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What have been the primary factors driving the upstream bioprocessing market’s growth?
The outsourcing of biopharmaceutical manufacturing is expected to propel the growth of the upstream bioprocessing market going forward. The outsourcing of biopharmaceutical manufacturing involves the delegation of certain stages of the production process to external entities, such as contract manufacturing organizations (CMOs) or contract development and manufacturing organizations (CDMOs). Outsourcing of biopharmaceutical manufacturing is driven by cost efficiency, focus on core competencies, flexibility in scaling production, access to specialized expertise, and risk mitigation. Outsourcing biopharmaceutical manufacturing in upstream bioprocessing market accelerates product development by leveraging external expertise, streamlining operations, and reducing costs. For instance, according to the BDO USA, a US member firm of BDO International, by 2025, contract development and manufacturing organizations and hybrid manufacturing companies will control 44% of the estimated 7,500kL of global mammalian capacity. Therefore, the outsourcing of biopharmaceutical manufacturing is driving the growth of the upstream bioprocessing market.
What are the key segments within the upstream bioprocessing market?
The upstream bioprocessing market covered in this report is segmented –
1) By Product type: Bioreactors, Fermenters, Cell Culture Media, Filters, Bags And Containers
2) By Workflow: Media Preparation, Cell Culture, Cell Separation
3) By Usage type: Single-Use, Multi-Use
4) By Mode: In House, Outsourced
5) By End User: Contract Development and Manufacturing Organization (CDMOs) Or Contract Research Organization (CROs), Research And Academic Institutes, Biopharmaceutical Companies
Subsegments:
1) By Bioreactors: Single-Use Bioreactors, Multi-Use Bioreactors
2) By Fermenters: Laboratory Fermenters, Pilot Scale Fermenters, Industrial Fermenters
3) By Cell Culture Media: Powdered Media, Liquid Media
4) By Filters: Sterile Filters, Air Filters, Capsule Filters
5) By Bags And Containers: Single-Use Bags, Bioprocess Containers, Storage Bags
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Which key players are shaping the upstream bioprocessing market?
Major companies operating in the upstream bioprocessing market are Thermo Fisher Scientific Inc., Danaher Corp, Merck KGaA, GE HealthCare Technologies, Parker Hannifin Corp, Corning Inc., AGC Biologics, Avantor, AGC Inc., Boehringer Ingelheim International GmbH, Catalent Inc., Sartorius AG, Entegris Inc., Getinge AB, Bio-Rad Laboratories Inc., Samsung Biologics Co. Ltd., Eppendorf AG, Repligen Corporation, Takara Bio Inc., KBI Biopharma Inc., Rentschler Biopharma SE, Just Biotherapeutics Inc., PBS Biotech Inc., Stobbe Group, Applikon Biotechnology
How will emerging trends drive the upstream bioprocessing market throughout the forecast period?
Major companies operating in the upstream bioprocessing market are focused on developing advanced bioreactors to meet the needs of cell culture processes that enhance performance, flexibility, and scalability. Bioreactors are essential tools in upstream bioprocessing, enabling the efficient and controlled production of biopharmaceuticals through cell culture and biomolecule production. For instance, in April 2023, Cytiva, a US-based provider of life sciences products and solutions, introduced X-platform bioreactors designed to streamline single-use upstream bioprocessing procedures. The bioreactors consist of a tank, cabinet assembly, and human-machine interface (HMI). This modular design allows flexible arrangements without custom hardware or single-use bags. User-friendly features include an optimized vessel with a full-opening door, baffles, and improved cable management. Additionally, the online Bioreactor Scaler tool helps determine optimal parameters for successful scale-up.
How do regional factors impact the upstream bioprocessing market, and which region is the largest contributor?
North America was the largest region in the upstream bioprocessing market in 2023. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the upstream bioprocessing market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
What Does The Upstream Bioprocessing Market Report 2025 Offer?
The upstream bioprocessing market research report from The Business Research Company offers global market size, growth rate, regional shares, competitor analysis, detailed segments, trends, and opportunities.
Upstream bioprocessing involves preparing and growing cells to produce biological products such as proteins and vaccines, focusing on cell line development, and cell culture. Upstream bioprocessing used to create a scalable system that maximizes yield and quality, ensuring reproducibility and efficiency for downstream purification and formulation.
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