How large is the adenosine deaminase-severe combined immunodeficiency market, and what is its growth trajectory?
The adenosine deaminase-severe combined immunodeficiency market size has grown strongly in recent years. It will grow from $5.57 billion in 2024 to $5.95 billion in 2025 at a compound annual growth rate (CAGR) of 6.9%. The growth in the historic period can be attributed to the increasing prevalence of severe combined immunodeficiency, rising incidence of PID, growing prevalence of immunodeficiencies, increasing healthcare investments, and increasing awareness of immunodeficiencies.
The adenosine deaminase-severe combined immunodeficiency market size is expected to see strong growth in the next few years. It will grow to $7.70 billion in 2029 at a compound annual growth rate (CAGR) of 6.6%. The growth in the forecast period can be attributed to the rising prevalence of genetic disorders, rising usage of bone marrow transplantation, increasing demand for non-conditioned stem cell transplantation, increasing prevalence of ADA deficiency, and rising number of adenosine deaminase deficiency (PDA). Major trends in the forecast period include technological advancements, adoption of gene therapy, government initiatives, advanced genetic testing, and advances in biotechnology.
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What are the key forces behind the adenosine deaminase-severe combined immunodeficiency market’s growth in recent years?
The rising prevalence of genetic disorders is expected to propel the growth of the adenosine deaminase-severe combined immunodeficiency market going forward. Genetic disorders refer to medical conditions caused by abnormalities or mutations in an individual’s DNA, either inherited or occurring spontaneously. The rising prevalence of genetic disorders is driven by factors such as improved diagnostic technologies, increased awareness, higher parental age, environmental influences, and population growth. The rising prevalence of genetic disorders, particularly in conditions such as adenosine deaminase-severe combined immunodeficiency (ADA-SCID), drives increased demand for advanced diagnostic methods and targeted treatments. For instance, in December 2022, according to a report published by the Department of Health & Social Care (DHSC), a UK-based government department, as of October 2022, around 33,000 whole genome equivalents were sequenced, with an average diagnostic yield of 32%, rising to 61% in specific conditions. Therefore, the rising prevalence of genetic disorders is driving the growth of the adenosine deaminase-severe combined immunodeficiency market.
What are the major segments of the adenosine deaminase-severe combined immunodeficiency market?
The adenosine deaminase-severe combined immunodeficiency market covered in this report is segmented –
1) By Treatment Type: Enzyme Replacement Therapy (ERT), Gene Therapy, Stem Cell Transplantation, Supportive Care Treatments
2) By Route of Administration: Intravenous, Subcutaneous, Oral
3) By Age Group: Pediatric (Infants and Children), Adults
4) By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies
5) By End-User: Hospitals, Specialty Clinics, Research Institutes, Others End-Users
Subsegments:
1) By Enzyme Replacement Therapy (ERT): Adenosine Deaminase Enzyme Replacement, Pegylated Erythropoietin (PEG-EPO)
2) By Gene Therapy: Autologous Stem Cell-Based Gene Therapy, Viral Vector-Mediated Gene Therapy
3) By Stem Cell Transplantation: HLA-Matched Bone Marrow Transplant, Umbilical Cord Blood Transplant
4) By Supportive Care Treatments: Antimicrobial Therapy, Immune System Support, Nutritional Support
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Which companies dominate the adenosine deaminase-severe combined immunodeficiency market?
Major companies operating in the adenosine deaminase-severe combined immunodeficiency market are Novartis AG, GlaxoSmithKline plc (GSK), Astellas Pharma, Orient EuroPharma, Charles River Laboratories, Chiesi Farmaceutici S.p.A., Spark Therapeutics, Rocket Pharmaceuticals, Bluebird Bio, Ospedale San Raffaele (OSR), Oxford Biomedica PLC, Teijin Pharma, Leadiant Biosciences, Orchard Therapeutics PLC, Fondazione Telethon, Mustang Bio Inc, Sigma-Tau Pharmaceuticals, Shenzhen Geno-Immune Medical Institute, ENZON Pharmaceuticals, QED Bioscience Inc.
What major trends will shape the adenosine deaminase-severe combined immunodeficiency market during the forecast period?
Major companies operating in the adenosine deaminase-severe combined immunodeficiency market are focusing on innovative therapies such as gene therapy for rare diseases to improve treatment outcomes, enhance patient survival, and address the underlying genetic causes of the disorder through advanced medical technologies. Gene therapy in adenosine deaminase-severe combined immunodeficiency (ADA-SCID) aims to correct the genetic defect by introducing a functional copy of the ADA gene, potentially providing a long-term cure for patients with this rare and life-threatening immune disorder. For instance, in May 2022, Danaher Corporation, a US-based life sciences and diagnostics innovator company, joined the Bespoke Gene Therapy Consortium (BGTC) as part of the Accelerating Medicines Partnership (AMP) program. In collaboration with the U.S. Food and Drug Administration (FDA), the National Institutes of Health (NIH), pharmaceutical companies, and non-profit organizations, this initiative aims to advance customized gene therapies for rare diseases and enhance development efficiency. This partnership is particularly significant as it represents a collective effort to address the challenges of traditional drug development for rare diseases—conditions that often receive limited commercial interest due to their low prevalence.
What are the key regional dynamics of the adenosine deaminase-severe combined immunodeficiency market, and which region leads in market share?
North America was the largest region in the adenosine deaminase-severe combined immunodeficiency market in 2024. The regions covered in the adenosine deaminase-severe combined immunodeficiency market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
What Does The Adenosine Deaminase-Severe Combined Immunodeficiency Market Report 2025 Offer?
The adenosine deaminase-severe combined immunodeficiency market research report from The Business Research Company offers global market size, growth rate, regional shares, competitor analysis, detailed segments, trends, and opportunities.
Adenosine deaminase-severe combined immunodeficiency (ADA-SCID) is a rare genetic disorder caused by a deficiency of the enzyme adenosine deaminase, leading to the toxic accumulation of metabolites that impair immune cell development. The purpose of understanding ADA-SCID is to diagnose and manage the condition early, preventing life-threatening infections and complications.
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