What is the current size and annual growth rate of the persistent epithelial defect management market?
The persistent epithelial defect management market size has grown rapidly in recent years. It will grow from $7.92 billion in 2024 to $9.29 billion in 2025 at a compound annual growth rate (CAGR) of 17.3%. The growth in the historic period can be attributed to increased research activities, higher demand for hospitals, increasing prevalence of ocular surface disorders, increasing prevalence of eye disorders, aging population.
The persistent epithelial defect management market size is expected to see rapid growth in the next few years. It will grow to $17.35 billion in 2029 at a compound annual growth rate (CAGR) of 16.9%. The growth in the forecast period can be attributed to increased partnerships and collaborations, growing awareness and education, focus on value based care, rising prevalence of conditions like diabetes and hypertension, early intervention and management. Major trends in the forecast period include technological advancements, increasing demand of innovative treatment types, advanced treatment modalities, availability of advanced surgical tools and techniques, innovative drugs.
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Which major factors have contributed to the expansion of the persistent epithelial defect management market?
The increasing prevalence of eye disorders is expected to propel the growth of the persistent epithelial defect management market going forward. Eye disorders refer to a broad range of medical conditions that affect the structure, function, or health of the eyes, leading to vision impairment, discomfort, or potential blindness. The prevalence of eye disorders is driven by factors such as aging populations, prolonged screen time, and environmental changes. Persistent epithelial defect management is essential for treating eye disorders, as it promotes healing, alleviates inflammation, and prevents complications such as infection or scarring. For instance, in December 2024, according to the World Health Organization, a Switzerland-based intergovernmental organization, the overall pooled prevalence of childhood myopia was 5.23% in 2023, with a significantly higher rate among females (4.90%) compared to males (3.94%). Therefore, the increasing prevalence of eye disorders drives the growth of the persistent epithelial defect management market.
Rise In Eye Surgeries Driving The Growth Of The Market
The rise in eye surgeries is expected to propel the growth of the persistent epithelial defect management market going forward. Eye surgeries refer to medical procedures performed on the eye to correct vision problems, treat diseases, or repair injuries. The rise in eye surgeries is attributed to the increasing prevalence of eye disorders such as cataracts, glaucoma, and refractive errors, advancements in surgical techniques, and the growing adoption of minimally invasive procedures. Persistent epithelial defect management enhances eye surgeries by promoting corneal healing, reducing complications, and improving visual outcomes through targeted treatments that support epithelial regeneration. For instance, in 2023, according to the Eye Bank Association of America, a US-based transplant association, domestic keratoplasty procedures grew by 2.7%, increasing from 49,597 in 2022 to 50,925 in 2023. Therefore, the rise in eye surgeries is driving the growth of the persistent epithelial defect management market.
How is the persistent epithelial defect management market segmented?
The persistent epithelial defect management market covered in this report is segmented –
1) By Disease Type: Epithalial Or Limbal, Inflammatory Disease, Neurotrophic Disease, Other Disease Types
2) By Distribution Channel: Direct Sales, Online Pharmacy, Retail Pharmacy, Hospitals
3) By End User: Hospital Or Clinical Laboratories, Physician Offices, Reference Laboratories, Other End Users
Subsegments:
1) By Epithelial Or Limbal: Limbal Stem Cell Deficiency (LSCD), Limbal Transplantation, Conjunctival Transplantation
2) By Inflammatory Disease: Dry Eye Syndrome, Allergic Conjunctivitis, Uveitis
3) By Neurotrophic Disease: Herpes Simplex Virus (HSV) Keratitis, Diabetic Neuropathy, Neurotrophic Keratopathy
4) By Other Disease Types: Chemical Burns, Trauma-Induced Defects, Congenital Corneal Opacities
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Who are the top competitors in the persistent epithelial defect management market?
Major companies operating in the persistent epithelial defect management market are AbbVie Inc., Novartis AG, Johnson & Johnson Vision, RegeneRx Biopharmaceuticals Inc., Regeneron Pharmaceuticals Inc., Alcon Inc., Bausch Health Companies Inc., Hoya Vision Care, Santen Pharmaceutical Co. Ltd., Recordati Rare Diseases Inc., Dompé Farmaceutici S.p.A., Lumenis Ltd., TissueTech Inc., Ocular Therapeutix Inc., Oculus Surgical Inc., Amber Ophthalmics Inc., Noveome Biotherapeutics Inc., OcuNexus Therapeutics Inc., Lux Bio Inc., Eyenovia Inc.
Which key trends are expected to influence the persistent epithelial defect management market in the coming years?
Major companies operating in the persistent epithelial defect management market are focusing on developing innovative therapies, such as secretome therapy, to accelerate healing and improve treatment outcomes for persistent epithelial defects. Secretome therapy refers to using bioactive molecules secreted by cells, such as proteins, lipids, and extracellular vesicles, to promote tissue repair, modulate immune responses, and treat various diseases. For instance, in April 2023, Kala Pharmaceuticals Inc., a US-based biopharmaceutical company, received U.S. Food and Drug Administration (FDA) Fast Track Designation for KPI-012, a human MSC-S therapy for persistent corneal epithelial defect. The drug’s multifactorial mechanism of action aims to address all underlying etiologies of persistent epithelial defect management by promoting corneal healing through bioactive molecules such as growth factors, protease inhibitors, and neurotrophic factors.
Which regional trends are influencing the persistent epithelial defect management market, and which area dominates the industry?
North America was the largest region in the persistent epithelial defect management market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the persistent epithelial defect management market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
What Does The Persistent Epithelial Defect Management Market Report 2025 Offer?
The persistent epithelial defect management market research report from The Business Research Company offers global market size, growth rate, regional shares, competitor analysis, detailed segments, trends, and opportunities.
Persistent Epithelial Defect (PED) Management refers to the medical strategies used to promote corneal healing in cases where the corneal epithelium fails to regenerate and close within two weeks despite standard treatment. It involves identifying and addressing underlying causes using therapeutic approaches such as lubricating eye drops, autologous serum tears, amniotic membrane transplantation, bandage contact lenses, and biologic therapies to facilitate epithelial healing and prevent corneal complications like ulcers or perforation.
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