The Business Research Company’s report on the Phosphoramidite Market provides insights into the global market size, growth rate, regional distribution, competitive landscape, key segments, emerging trends, and strategic opportunities.
How are market drivers shaping the future growth trajectory of the phosphoramidite industry?
The expansion of the biopharmaceutical sector is expected to propel the growth of the phosphoramidite market going forward. The biopharmaceutical sector refers to the industry involved in the research, development, production, and commercialization of biologically derived medical products, including vaccines, gene therapies, monoclonal antibodies, and recombinant proteins. The expansion of the biopharmaceutical sector is due to advancements in biotechnology, the increasing prevalence of chronic diseases, and rising investments in research and development. Biotechnology innovations, such as gene editing and monoclonal antibody therapies, have created more effective and targeted treatments. The expansion of the biopharmaceutical sector will support phosphoramidite demand as it plays a key role in synthesizing DNA and RNA for gene therapies, mRNA vaccines, and oligonucleotide-based drugs. As these therapies gain traction, the need for phosphoramidites to produce synthetic nucleic acids will rise, boosting their use in biopharmaceutical research and production. For instance, according to the UK government, the core biopharmaceutical sector generated £46.7 ($58.4 billion) billion in revenue during 2022, representing 43% of the total turnover of the life sciences industry. Further, the sector supports over 126,000 jobs and has experienced substantial growth in research and development investments. Therefore, the expansion of the biopharmaceutical sector is driving the growth of the phosphoramidite market.
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What is the estimated market size of the phosphoramidite sector by 2029, based on current forecasts?
The phosphoramidite market size has grown strongly in recent years. It will grow from $1.01 billion in 2024 to $1.09 billion in 2025 at a compound annual growth rate (CAGR) of 7.7%. The growth in the historic period can be attributed to increasing demand for DNA and RNA synthesis, rising adoption of mRNA-based therapeutics, rising prevalence of genetic disorders, growing demand for synthetic biology, and growing investments in genomic research.
The phosphoramidite market size is expected to see strong growth in the next few years. It will grow to $1.44 billion in 2029 at a compound annual growth rate (CAGR) of 7.4%. The growth in the forecast period can be attributed to increasing utilization of phosphoramidites, rising demand for custom DNA and RNA synthesis, growing need for high-purity phosphoramidites, growing focus on personalized medicine, and rising biopharmaceutical companies. Major trends in the forecast period include synthetic biology expansion, development of novel phosphoramidite chemistries, advancements in genomic technologies, development activities in biotechnology, and development of personalized medicine.
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Who are the top players in the phosphoramidite market?
Major companies operating in the phosphoramidite market are Thermo Fisher Scientific Inc., Agilent Technologies Inc., Aragen Life Sciences, Twist Bioscience, Innovassynth Technologies (I) Ltd., Tokyo Chemical Industry Co. Ltd. (TCI), Aurigene Services, Eurofins Genomics, LGC Biosearch Technologies, Link Technologies Ltd., Creative Biolabs, Biosynth Carbosynth, TriLink BioTechnologies, ChemGenes Corporation, Berry & Associates Inc., Lumiprobe Corporation, Hongene Biotech Corporation, Carbolink India Pvt. Ltd., PolyOrg Inc., Glen Research, Gene Link Inc., emp BIOTECH GmbH
What are the major trends in the phosphoramidite market?
Major companies operating in the phosphoramidite market are focusing on developing advanced DNA synthesis services to enhance accuracy, speed, and sustainability while reducing hazardous waste in DNA manufacturing. DNA synthesis is a method of creating DNA sequences using enzymes instead of chemical reagents, offering higher accuracy, speed, and sustainability. For instance, in April 2022, Ansa Biotechnologies Inc., a US-based biotechnology company, announced the closure of an oversubscribed $68 million Series A financing round led by Northpond Ventures, with participation from various new and existing investors. This funding aims to accelerate the development of Ansa’s next-generation enzymatic DNA synthesis technology, also called phosphoramidite synthesis, expand its R&D and manufacturing facilities, and launch a customizable DNA synthesis service. The company, a spinout from the University of California, Berkeley, utilizes a patented method that allows for the rapid and accurate synthesis of long DNA sequences, addressing current bottlenecks in the industry.
Which geography holds the highest phosphoramidite market share?
North America was the largest region in the phosphoramidite market in 2024. Europe is expected to be the fastest-growing region during the forecast period. The regions covered in the phosphoramidite market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
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How do different segments contribute to the overall expansion of the phosphoramidite market?
The phosphoramidite market covered in this report is segmented –
1) By Type: Deoxyribonucleic Acid (DNA) Phosphoramidites, Ribonucleic Acid (RNA) Phosphoramidites, Labeled Phosphoramidites, Modifier Phosphoramidites, Other Types
2) By Synthesis Method: H-Phosphonate Method, Phosphoramidite Method, Trivalent Phosphorus Compounds Method
3) By Application: Gene Synthesis, Deoxyribonucleic Acid (DNA) Sequencing, Deoxyribonucleic Acid (DNA) Amplification
4) By End-User: Academic Research, Pharmaceutical Industry, Biotechnology Industry
Subsegments:
1) By Deoxyribonucleic Acid (DNA) Phosphoramidites: Standard DNA Phosphoramidites, Degenerate DNA Phosphoramidites, Methylated DNA Phosphoramidites, Backbone-Modified DNA Phosphoramidites
2) By Ribonucleic Acid (RNA) Phosphoramidites: Standard RNA Phosphoramidites, 2′-O-Methyl RNA Phosphoramidites, 2′-Fluoro RNA Phosphoramidites, 2′-O-TBDMS Protected RNA Phosphoramidites
3) By Labeled Phosphoramidites: Fluorescent-Labeled Phosphoramidites, Biotin-Labeled Phosphoramidites, Digoxigenin-Labeled Phosphoramidites, Radioisotope-Labeled Phosphoramidites
4) By Modifier Phosphoramidites: Amine-Modified Phosphoramidites, Thiol-Modified Phosphoramidites, Spacer Phosphoramidites, Azide-Modified Phosphoramidites
5) By Other Types: Chimeric Phosphoramidites, Phosphorothioate Phosphoramidites, PEGylated Phosphoramidites, Photo-Cleavable Phosphoramidites
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How is the phosphoramidite market defined, and what are its core characteristics?
Phosphoramidite is a chemical compound commonly used in the synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) through solid-phase synthesis. It consists of a phosphate group linked to an amine (-NR2) and is highly reactive, allowing for the stepwise addition of nucleotide bases in oligonucleotide synthesis. Phosphoramidites are crucial in producing synthetic nucleic acids for research, diagnostics, and therapeutic applications.
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