The Business Research Company’s report on the Propionic Acidemia Market provides insights into the global market size, growth rate, regional distribution, competitive landscape, key segments, emerging trends, and strategic opportunities.
How are market drivers shaping the future growth trajectory of the propionic acidemia industry?
The increasing prevalence of genetic disorders is expected to propel the growth of the propionic acidemia market going forward. Genetic disorders refer to the conditions caused by mutations or abnormalities in an individual’s DNA, which can be inherited or occur spontaneously, affecting health and development. The increasing prevalence of genetic disorders is due to consanguineous marriages, as they increase the risk of inheriting recessive genetic mutations by allowing the same defective genes to be passed down from both parents, which significantly raises the likelihood of genetic conditions. Propionic acidemia enhances genetic disorder management by offering targeted treatments that address metabolic imbalances, improving patient outcomes. For instance, in July 2022, according to the report published by the Cystic Fibrosis (CF) Foundation, a US-based non-profit organization, the prevalence of cystic fibrosis has risen, affecting nearly 40,000 children and adults in the United States in 2022, with over 105,000 diagnosed globally. Therefore, the increasing prevalence of genetic disorders is driving the growth of the acidemia market.
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What is the estimated market size of the propionic acidemia sector by 2029, based on current forecasts?
The propionic acidemia market size has grown steadily in recent years. It will grow from $2.00 billion in 2024 to $2.09 billion in 2025 at a compound annual growth rate (CAGR) of 4.8%. The growth in the historic period can be attributed to the rise in disease prevalence, increase in newborn screening, rise in healthcare expenditure, increase in pediatric diagnoses, and growth in rare disease initiatives.
The propionic acidemia market size is expected to see steady growth in the next few years. It will grow to $2.49 billion in 2029 at a compound annual growth rate (CAGR) of 4.4%. The growth in the forecast period can be attributed to increasing awareness campaigns, rising metabolic disorder cases, growing telemedicine adoption, increasing personalized treatment demand, and increasing healthcare investments. Major trends in the forecast period include technological advancements in diagnostics, development of gene therapies, advancements in metabolic therapies, integration of AI in healthcare, and development of novel therapeutics.
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Who are the top players in the propionic acidemia market?
Major companies operating in the propionic acidemia market are Moderna Therapeutics, Synlogic Therapeutics, Invitae Corporation, Global Calcium, BridgeBio Pharma, AdvaCare Pharma, HemoShear Therapeutics, DNA Labs, Velnex Medicare, Phytologix Life Scieneces, Liaoning Koncepnutra Co. Ltd., Propionic Acidemia Foundation, Agex Pharma, Gladfem, CSL Behring, Octapharma AG, Sanquin, Kedrion SpA, Shire plc, Vitane Pharmaceuticals Inc.
What are the major trends in the propionic acidemia market?
Major companies operating in the propionic acidemia market are focusing on developing innovative mRNA-based treatments to address the underlying genetic causes of the disease. mRNA therapies are a type of treatment that use messenger RNA to instruct cells to produce proteins that can prevent or treat diseases by targeting the underlying causes at a genetic level. For instance, in May 2023, Moderna, a US-based pharmaceutical and biotechnology company, presented interim data from the Phase 1/2 trial of mRNA-3927, an investigational mRNA therapy for propionic acidemia. The therapy uses mRNA to deliver functional copies of the PCCA and PCCB genes, restoring enzyme activity in the liver and potentially reducing metabolic decompensations, with this innovative treatment approach aiming to improve patient outcomes by addressing the genetic root cause of the disease, offering new hope for individuals affected by this rare metabolic disorder.
Which geography holds the highest propionic acidemia market share?
North America was the largest region in the propionic acidemia market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the propionic acidemia market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
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How do different segments contribute to the overall expansion of the propionic acidemia market?
The propionic acidemia market covered in this report is segmented –
1) By Drug Class: L-Carnitine, Antibiotics
2) By Route of Administration: Oral, Intravenous, Intramuscular
3) By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies
Subsegments:
1) By L-Carnitine Drug Class: Oral L-Carnitine, Injectable L-Carnitine
2) By Antibiotics Drug Class: Oral Antibiotics, Injectable Antibiotics
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How is the propionic acidemia market defined?
Propionic Acidemia (PA) is a rare, inherited metabolic disorder caused by a deficiency in the enzyme propionyl-CoA carboxylase, which is essential for breaking down certain amino acids and fatty acids. This deficiency leads to the accumulation of toxic compounds in the blood, causing severe symptoms such as metabolic crises, neurological damage, and, if left untreated, can be life-threatening, especially in infancy.
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